Tottenham exited its second competition in four days after losing 2-0 at Crystal Palace in the fourth round of the FA Cup on Sunday, and defending champion Chelsea was boosted by two video reviews in beating Sheffield Wednesday 3-0.
Palace took a ninth-minute lead when Jeff Schlupp’s shot was saved by Paulo Gazzaniga but the Spurs goalkeeper could only push the ball into the path of Connor Wickham and he scored with a routine tap-in for his first goal in 799 days.
The hosts extended their advantage after Kyle Walker-Peters handled in the penalty area with Wickham lurking. Former Tottenham winger Andros Townsend slammed the resulting spot kick straight down the middle in the 34th.
Tottenham got a penalty of its own 10 minutes later when Patrick Van Aanholt brought down Juan Foyth, but Kieran Trippier fired well wide to ensure the Eagles took a 2-0 lead into the break. Pochettino introduced Erik Lamela as a halftime substitute, but Spurs continued to struggle in front of goal in the absence of Christian Eriksen and the injured Dele Alli and Harry Kane.
Chelsea beat Tottenham in a penalty shootout on Thursday in the English League Cup semifinals after a 2-1 victory for Chelsea at Stamford Bridge left the two sides level 2-2 on aggregate.
The fifth-round draw takes place Monday.